Oncovirology Laboratory

Decoding how viruses drive human cancer

At the Aguayo Lab we investigate the interplay between oncogenic DNA viruses and environmental cofactors in the development of human cancer — from cervix and head & neck to lung, breast and gastrointestinal tumors.

HPV Epstein–Barr virus Polyomaviruses Environmental carcinogens
15%
of cancers worldwide are linked to infections
85+
peer-reviewed publications
9
funded research projects
30+
years studying oncogenic viruses
About the lab

Viruses, the environment, and the origins of cancer

The Aguayo Laboratory is part of the Department of Biomedical Sciences, Faculty of Medicine, Universidad de Tarapacá, in Arica, Chile. Led by Prof. Francisco Aguayo, PhD, we study the relationship between viral infections and cancer development.

Roughly 15% of the global cancer burden is etiologically related to infections. We focus on oncogenic DNA viruses — including human papillomavirus (HPV), Epstein–Barr virus (EBV) and polyomaviruses — and on how environmental carcinogens such as tobacco smoke, benzo[a]pyrene and aflatoxin cooperate with them to reshape epithelial cells toward malignancy.

See our research lines →
Fluorescence microscopy — Oncovirology Laboratory
What we study

Four interconnected research lines

From classic oncoviruses to emerging agents, and the carcinogens that amplify their effect.

HPV & epithelial cancer

High-risk human papillomavirus in cervical, oropharyngeal, anogenital and other epithelial tumors.

EBV & cofactors

Epstein–Barr virus reactivation driven by tobacco smoke and benzo[a]pyrene in lung carcinogenesis.

Virus–carcinogen synergy

Cooperation between viral oncoproteins and chemical carcinogens such as aflatoxin and BaP.

Emerging oncoviruses

MMTV-like viruses, Torque Teno virus, polyomaviruses and virus–microbiome interactions.

Latest output

Recent publications

2026

Genotoxic Bacteria and Oncogenic Viruses in Colorectal Cancer: Evidence, Gaps, and a Proposed Interaction Model Review

Salazar-Ulbrich N, Haro-Solis D, Aguayo F, et al. · Int. J. Molecular Sciences

2025

Prevalence of Torque Teno Virus (TTV) in Cervical Precursor Lesions and Cancer in Chilean Women

Guzmán-Venegas M, Moreno-León C, Andrade-Madrigal C, et al. · Int. J. Molecular Sciences

Interested in joining us?

We welcome motivated undergraduate, master's and doctoral students with an interest in virology, molecular oncology and cell biology.

Get in touch